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Related Experiment Video

Updated: Oct 28, 2025

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

Bleomycin sclerotherapy for large diffuse microcystic lymphatic malformations.

Lingling Sheng¹, Ziyou Yu¹, Shengli Li¹

¹Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

|July 16, 2021

Summary

This summary is machine-generated.

Bleomycin sclerotherapy is effective for treating large microcystic lymphatic malformations (LMs). This method, combining lavage and injection, shows good results with few complications, making it a primary therapy for LMs.

Keywords:

Pulmonary fibrosis bleomycin injection microcystic lymphatic malformations (microcystic LMs)sclerotherapy

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Last Updated: Oct 28, 2025

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Published on: June 28, 2018

Area of Science:

Vascular Surgery
Dermatology
Pediatric Surgery

Background:

Microcystic lymphatic malformations (LMs) are congenital vascular anomalies.
Lesions are characterized by small cysts (<1 cm diameter).
Bleomycin sclerotherapy is established for macrocystic LMs.

Purpose of the Study:

To evaluate the safety and efficacy of bleomycin sclerotherapy for large, diffuse microcystic LMs.
To assess outcomes and complications of the treatment.

Main Methods:

Ultrasound used to determine lesion location and size in 46 patients.
Bleomycin lavage for larger cysts and intradermal injection for superficial lesions.
Outcomes and complications were systematically assessed.

Main Results:

Large diffuse microcystic LMs commonly found in the neck, abdominal wall, and chest.
Average lesion size was 10.6 cm x 7.2 cm.
Excellent (69.6%) or moderate (23.9%) responses observed.
No recurrence in patients with long follow-up.
Common complications included swelling, hemorrhage, and fever; no lung fibrosis noted.

Conclusions:

Combined bleomycin lavage and intradermal injection is effective and safe for large diffuse microcystic LMs.
The treatment offers good therapeutic effects with low complication rates.
This approach is recommended as a primary therapy for microcystic LMs.