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A Rare Variant of Meningioma: Case Report and Review of Literature
Elizabeth Joseph1, Rojin Abraham2, Sujin Koshy3
1Department of Pathology, Believers Church Medical College, Thiruvalla, Kerala, India.
Abstract:
Meningioma is a morphologically heterogeneous tumour arising from meningothelial cells that has been classified by the World Health Organization into 15 different histological types and graded into three types groups (Grade I, II, and III) based on the biological behavior. Metaplastic meningioma is a rare subtype of meningioma characterized by focal or widespread mesenchymal differentiation in the form of bone, cartilage, fat, or xanthomatous tissue elements. Xanthomatous meningioma is a subclass of metaplastic meningioma which is exceedingly rare. Only a few cases have been reported in the literature. Here, we report the case of a 44-year-old man, who presented with left sided weakness and was diagnosed as a case of xanthomatous meningioma.
Insights
Xanthomatous meningioma, an exceedingly rare subtype of metaplastic meningioma, presents unique diagnostic challenges. This report details a case in a 44-year-old male exhibiting left-sided weakness.
Area of Science:
- Neuropathology
- Oncology
Background:
- Meningiomas are WHO-classified tumors of meningothelial cells, with diverse histological types and grades.
- Metaplastic meningiomas exhibit mesenchymal differentiation (bone, cartilage, fat, xanthomatous tissue).
- Xanthomatous meningioma is an exceptionally rare subclass of metaplastic meningioma.
Observation:
- A 44-year-old male presented with left-sided weakness.
- Diagnostic workup led to the identification of a xanthomatous meningioma.
Findings:
- The case highlights the clinical presentation and diagnostic confirmation of xanthomatous meningioma.
- This rare tumor subtype requires careful pathological evaluation.
Implications:
- Adds to the limited literature on xanthomatous meningioma.
- May inform diagnostic and treatment strategies for rare meningioma variants.
