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Late radiation effects in the mouse brain. A quantitative study on PAS positive deposits
1Department of Neurological Surgery, School of Medicine, University of Tsukuba, Ibaraki, Japan.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1987
Summary
Whole brain irradiation in mice was studied for its effects on brain deposits. Higher radiation doses significantly reduced the formation of these deposits in the thalamic nucleus.
Area of Science:
- Neuroscience
- Radiation Biology
- Pathology
Background:
- Post-irradiation changes in the brain are not fully understood.
- The ventral thalamic nucleus is a brain region susceptible to radiation damage.
- Periodic acid-Schiff (PAS) positive deposits are observed in specific brain regions.
Purpose of the Study:
- To investigate the effect of whole brain irradiation on PAS positive deposits in the mouse ventral thalamic nucleus.
- To determine the dose-dependency and time course of these changes.
Main Methods:
- Mice underwent whole brain irradiation with single doses from 13 to 25 Gy.
- PAS positive deposits in the dorsal part of the ventral thalamic nucleus were quantified.
- Microscopic scoring was performed at intervals between 20 and 85 weeks post-irradiation.
Main Results:
- A significant dose-dependent inhibition of PAS positive deposit formation was observed.
- The reduction in deposits was correlated with the radiation dose received.
- These effects were noted across various time points after irradiation.
Conclusions:
- Whole brain irradiation inhibits the formation of PAS positive deposits in the ventral thalamic nucleus in a dose-dependent manner.
- This finding provides insights into the neuropathological effects of radiation.
- Further research may explore the mechanisms underlying this inhibition.