Pediatric antimicrobial stewardship practices at discharge: A national survey

Marie E Wang1, Kimberly Felder2, Jason G Newland3

  • 1Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

Insights

Pediatric antimicrobial stewardship programs (ASPs) rarely review discharge prescriptions. Improving this process during hospital-to-home transitions is a key opportunity for better antimicrobial use in children.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Stewardship
  • Health Services Research

Background:

  • Antimicrobial stewardship programs (ASPs) are crucial for optimizing antibiotic use in pediatric healthcare settings.
  • The transition of care from hospital to home presents unique challenges for continuing effective antimicrobial management.
  • Discharge antimicrobial prescriptions require careful oversight to prevent inappropriate use and promote patient safety.

Purpose of the Study:

  • To assess the current landscape of discharge stewardship practices within pediatric antimicrobial stewardship programs.
  • To identify the extent to which pediatric ASPs review antimicrobial prescriptions at the time of patient discharge.
  • To highlight opportunities for enhancing antimicrobial stewardship during the critical hospital-to-home transition.

Main Methods:

  • A survey was distributed to pediatric antimicrobial stewardship program (ASP) site leaders.
  • The survey focused on current practices related to the review of discharge antimicrobial prescriptions.
  • Data were collected from participants within the Sharing Antimicrobial Reports for Pediatric Stewardship collaborative.

Main Results:

  • Out of 67 surveyed sites, only 13 (19%) reported that their ASP reviews discharge antimicrobial prescriptions.
  • This indicates a low prevalence of formal ASP involvement in managing antibiotics prescribed at discharge.
  • The findings suggest a significant gap in discharge stewardship practices across pediatric facilities.

Conclusions:

  • Discharge stewardship represents a substantial, underutilized opportunity for improving antimicrobial use in pediatric populations.
  • Enhancing ASP involvement in reviewing discharge prescriptions is essential for optimizing patient care and combating antimicrobial resistance.
  • Targeted interventions are needed to support pediatric ASPs in implementing robust discharge stewardship protocols.

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
48
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.2K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
58
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
57
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
44
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
46