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Updated: Oct 28, 2025
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
Published on: September 20, 2020
Factors influencing postembolization syndrome in patients with hepatocellular carcinoma undergoing first
Jing-Jing He1, Xi-Xi Yin1, Ting Wang1
1Sun Yat-Sen University Cancer Center, Guangdong, China.
Context:
Postembolization syndrome (PES) is the most common complication in patients with hepatocellular carcinoma (HCC) who had undergone transcatheter arterial chemoembolization (TACE). PES was defined as fever, nausea and/or vomiting, and abdominal pain and these symptoms develop within 1-3 days after TACE. However, few studies have explored the factors influencing PES in patients with TACE for the first time.
Aims:
We explored the factors influencing PES in patients with HCC undergoing TACE for the first time.
Settings And Design:
The present study was a hospital-based study conducted in the tertiary care hospital of Guangzhou with a retrospective study design.
Subjects And Methods:
In this single-center retrospective study, a total of 242 patients with HCC were included in the first TACE program between November 1, 2018 and November 31, 2019.
Statistical Analysis Used:
T-test and Chi-square test revealed the factors affecting the occurrence of PES. Correlation analysis (Spearman) explored the relationship between these factors and PES. Binary logistics analyzed the predictive factors of PES.
Results:
The probability of PES in patients with HCC undergoing TACE for the first time was 55.45%. Types of embolic agents (r = 0.296), types of microspheres (r = 0.510), number of microspheres (r = 0.130), maximum diameter of microspheres used (r = 0.429), type of drug (r = 0.406), and drug loading (r = 0.433) were positively correlated with PES (P < 0.05). Serum albumin was negatively correlated with PES (P = 0.008, r = -0.170). Binary logistic regression analysis revealed that drug loading microspheres (odds ratio [OR] = 0.075, 95% confidence interval [CI] = 0.031-0.180) and serum albumin (OR = 0.182, 95% CI = 0.068-0.487) were the protective factors influencing PES, while drug loading was the risk factor of PES (OR = 1.407, 95% CI = 1.144-1.173).
Conclusions:
Drug loading microspheres, serum albumin, and drug loading were the predictors of PES after the first TACE.
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