Related Experiment Video
Updated: Oct 28, 2025
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Ocular mucous membrane pemphigoid: novel treatment strategies
Samir Jabbour1, Maria Phylactou1, Sajjad Ahmad1,2
1Moorfields Eye Hospital NHS Foundation Trust.
Purpose Of Review:
To describe current treatments of ocular mucous membrane pemphigoid (OMMP), including conventional systemic immunosuppression (CIST) and novel biologic agents.
Recent Findings:
CIST remains the main stay therapy for the management of OMMP. The choice of agents is tailored to disease severity - mild disease is treated with dapsone, whereas moderately severe cases are often treated with mycophenolate mofetil or sulfa-based drugs and severe cases are treated with cyclophosphamide. In recalcitrant disease newer biologics such as Rituximab, intravenous immunoglobins and tumour necrosis alpha antagonists have proven to be effective in disease control. Control of inflammation with topical therapy and halting conjunctival fibrosis remain as areas of unmet clinical needs.
Summary:
OMMP is largely treated with CIST. The recent introduction of new biologic agents could shape the way the disease is treated in the near future.
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