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Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction
Jan-Per Wenzel1,2, Ramona Bei der Kellen3, Christina Magnussen4,5
1Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany. ja.wenzel@uke.de.
Summary
Diastolic dysfunction (DD) affects 12.7% of the general population, with 1.3% having DD with heart failure with preserved ejection fraction (HFpEF). Risk factors differ between DD with and without HFpEF, suggesting distinct underlying mechanisms.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Left ventricular diastolic dysfunction (DD) is frequently observed in the general population.
- DD is a known contributor to heart failure with preserved ejection fraction (HFpEF).
Purpose of the Study:
- To determine the prevalence of DD in a general population sample.
- To identify correlates of DD in individuals with and without HFpEF.
Main Methods:
- Analysis of 5913 participants from the Hamburg City Health Study (HCHS).
- Assessment of diastolic dysfunction (DD) using echocardiographic parameters.
- Multivariable regression analysis adjusted for cardiovascular risk factors.
Main Results:
- Diastolic dysfunction (DD) was present in 12.7% of participants.
- 1.3% of participants had DD with HFpEF (DDwHFpEF), while 11.2% had DD without HFpEF (ALVDD).
- ALVDD was associated with arterial hypertension and HbA1c. DDwHFpEF was associated with age, BMI, LVMI, female sex, atrial fibrillation, CAD, COPD, and QRS duration.
Conclusions:
- The prevalence of DD in this cohort was 12.7%, with 1.3% having HFpEF.
- DD with and without HFpEF exhibit distinct associations with cardiovascular risk factors and comorbidities.
- Further research is warranted to understand the distinct pathophysiological roles of ALVDD and DDwHFpEF.
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