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Updated: Oct 28, 2025
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Intersection Between Chronic Kidney Disease and Cardiovascular Disease
Luke J Laffin1, George L Bakris2
1Section of Preventive Cardiology and Rehabilitation, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Current Cardiology Reports
|July 16, 2021
Summary
Cardiovascular disease and chronic kidney disease share risk factors and mechanisms. Managing cardiovascular health in kidney patients is vital due to higher heart disease prevalence.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Global chronic kidney disease (CKD) incidence is rising.
- Cardiovascular disease (CVD) incidence has plateaued after a period of decline.
- Understanding the interplay between CKD and CVD is critical.
Purpose of the Study:
- To review the shared risk factors and pathogenic mechanisms of CKD and CVD.
- To discuss current cardiovascular treatment strategies for patients with CKD.
- To focus on atherosclerotic cardiovascular disease and heart failure in the context of CKD.
Main Methods:
- Literature review of shared risk factors and mechanisms.
- Analysis of contemporary cardiovascular treatment considerations.
- Focus on specific CVD manifestations (atherosclerotic CVD, heart failure) in CKD patients.
Main Results:
- CKD and CVD share common risk factors and pathogenic pathways.
- Patients with CKD have a higher likelihood of developing CVD than progressing to end-stage renal disease.
- Contemporary treatments for atherosclerotic CVD and heart failure in CKD require specific considerations.
Conclusions:
- The convergence of CKD and CVD necessitates integrated management approaches.
- Addressing shared risk factors is key to mitigating cardiovascular risk in CKD patients.
- Tailored cardiovascular therapies are essential for improving outcomes in individuals with chronic kidney disease.
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