Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality

Area of Science:

• Infectious Diseases
• Cardiology
• Nephrology

Background:

• Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness.
• Andes virus is a significant cause of HCPS in South America.
• The prognostic value of proteinuria in HCPS requires further elucidation.

Purpose of the Study:

• To investigate the frequency of proteinuria in patients with Andes virus-induced HCPS.
• To assess the association between proteinuria and mortality in HCPS patients.

Main Methods:

• Observational analytical study conducted across 12 health centers in Chile (2001-2018).
• Included patients with confirmed Andes virus HCPS and proteinuria assessment at admission.
• Prospective data collection on patient demographics, clinical course, and outcomes.

Main Results:

• Proteinuria was detected in 77% of the 95 evaluated HCPS patients.
• Patients with proteinuria exhibited a significantly higher mortality rate (26% vs. 5%, p=0.036).
• Proteinuria was associated with a relative risk of 1.3 for increased mortality (p=0.002).

Conclusions:

• Proteinuria is a frequent clinical finding in patients diagnosed with HCPS.
• The presence of proteinuria is a significant indicator of increased mortality risk in HCPS.