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Published on: June 23, 2020
A mitochondria-targeted fluorescent probe for real-time imaging SO2/H2O2
Yang Wang1, Ru-Xing Chen2, Rui Tian3
1Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Abstract:
Studies have shown that changes in the redox state of cells might be closely related to pathological and physiological processes. Sulfur dioxide and hydrogen peroxide, as a significant redox couple in living cells, are endogenously produced by cells. Here, we report a long-wavelength fluorescent probe to reversibly monitor sulfur dioxide and hydrogen peroxide. This probe (NBD) displayed high selectivity and sensitivity, which could be accumulated in mitochondria for real-time imaging of SO2/H2O2. These results indicated that NBD would be an ideal tool for monitoring the redox cycle state in living cells.
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