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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Effect of Home-Based Exercise Program on Physical Function and Balance in Older Adults With Sarcopenia: A Multicenter

Ekin Ilke Sen, Sibel Eyigor, Merve Dikici Yagli

    Journal of Aging and Physical Activity
    |July 16, 2021
    PubMed
    Summary

    A home-based exercise program significantly improved physical function and balance in patients with sarcopenia. This intervention enhanced the 6-minute walking test and Berg Balance Scale scores, boosting quality of life.

    Keywords:
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    Area of Science:

    • Gerontology
    • Rehabilitation Medicine
    • Physical Therapy

    Background:

    • Sarcopenia, characterized by age-related loss of muscle mass and strength, significantly impacts mobility and quality of life.
    • Effective interventions are crucial to mitigate the functional decline associated with sarcopenia.

    Purpose of the Study:

    • To evaluate the efficacy of a home-based exercise program in improving physical function, balance, and quality of life in patients diagnosed with sarcopenia.

    Main Methods:

    • A prospective, randomized, controlled multicenter study involving 100 patients with sarcopenia.
    • Participants were assigned to either a home-based exercise group or a control group.
    • The exercise program included progressive posture, stretching, muscle strengthening, balance, coordination, and gait training over 3 months.

    Main Results:

    • The home-based exercise group demonstrated significant improvements in the 6-minute walking test and Berg Balance Scale scores compared to controls.
    • Significant reductions in the timed up and go test scores were observed in the exercise group.
    • Quality of life showed a significant improvement in patients undertaking the home-based exercise program.

    Conclusions:

    • A home-based exercise program is an effective intervention for enhancing physical function and balance in individuals with sarcopenia.
    • This exercise regimen positively impacts the quality of life for patients suffering from sarcopenia.