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Relationship between the structure and function of the transcriptional regulator E2A

Jia-Jie Liang1,2,3, Hu Peng2,4, Jiao-Jiao Wang1

  • 1Medical College, China Three Gorges University, 8 Daxue Road, Xiling District, Yichang, 443002, China.

Journal of Biological Research (Thessalonike, Greece)
|July 17, 2021
PubMed
Summary

E2A proteins regulate lymphocyte development by forming dimers that bind DNA and interact with coactivators or corepressors. This structural mechanism controls gene expression, impacting cell differentiation and potential therapeutic targets.

Keywords:
Activation domainE2AStructural basisbHLH domain

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