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Area of Science:

  • Dermatology
  • Trichology

Background:

  • Frontal fibrosing alopecia (FFA) is a primary cicatricial alopecia first identified in 1994.
  • FFA incidence has risen dramatically, becoming the leading cause of cicatricial alopecia globally.
  • It primarily affects postmenopausal women, characterized by receding hairline and eyebrow loss.

Purpose of the Study:

  • To provide a comprehensive review of frontal fibrosing alopecia.
  • To discuss the pathogenesis, epidemiology, clinical presentation, histology, and treatment strategies for FFA.

Main Methods:

  • Literature review of existing studies on frontal fibrosing alopecia.
  • Analysis of clinical, histological, and epidemiological data.

Main Results:

  • FFA presents a distinct phenotype, histologically similar to lichen planopilaris (LPP) but with unique patterned hair loss.
  • Pathophysiology remains debated despite reported familial cases and genetic associations.
  • FFA is progressive without treatment, and therapeutic responses are frequently unsatisfactory.

Conclusions:

  • Frontal fibrosing alopecia is a significant and growing dermatological concern.
  • Further research into FFA pathophysiology is crucial for developing effective treatments.
  • Understanding FFA's unique characteristics is key for accurate diagnosis and management.