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A dermatologic perspective on multisystem inflammatory syndrome in children

Fludiona Naka1, Laura Melnick1, Mark Gorelik2

  • 1New York Presbyterian/Columbia University Medical Center, New York, New York, USA.

Clinics in Dermatology
|July 17, 2021
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) is a new condition linked to COVID-19. It causes prolonged fever, skin rashes, and abdominal pain in children, with a focus on its mucocutaneous symptoms.

Area of Science:

  • Pediatric immunology
  • Infectious diseases
  • Public health

Background:

  • An emerging immune-mediated syndrome, multisystem inflammatory syndrome in children (MIS-C), has been identified in children.
  • MIS-C is associated with the coronavirus disease 2019 (COVID-19) pandemic.
  • The syndrome's incidence follows the initial infectious assault by several weeks.

Purpose of the Study:

  • To review current literature on MIS-C.
  • To understand the clinical presentation of MIS-C.
  • To focus on the mucocutaneous manifestations of MIS-C.

Main Methods:

  • Literature review of published data on MIS-C.
  • Analysis of clinical phenotypes and symptoms.
  • Focus on mucocutaneous features.

Main Results:

  • MIS-C presents with prolonged fever, skin eruptions, neck stiffness, and gastrointestinal issues.
  • Abdominal pain is a prominent gastrointestinal symptom.
  • Shock and organ dysfunction can occur, but respiratory distress is typically absent.

Conclusions:

  • MIS-C is a significant pediatric condition associated with COVID-19.
  • Understanding its diverse manifestations, particularly mucocutaneous signs, is crucial for diagnosis and management.
  • Further research is needed to elucidate the pathophysiology and long-term outcomes of MIS-C.

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