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C-reactive protein in children with obstructive sleep apnea and effects of adenotonsillectomy

Kun-Tai Kang1, Wen-Chin Weng2, Pei-Lin Lee3

  • 1Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; Department of Otolaryngology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan; Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan.

Auris, Nasus, Larynx
|July 17, 2021
PubMed

Insights

Children with obstructive sleep apnea (OSA) have elevated C-reactive protein (CRP) levels. Adenotonsillectomy significantly reduced CRP in children with OSA and abnormal CRP levels, indicating treatment effectiveness.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Biomarkers of Inflammation

Background:

  • C-reactive protein (CRP) is a key serum marker for inflammation linked to cardiovascular disease.
  • Childhood obstructive sleep apnea (OSA) is a prevalent condition with potential long-term health consequences.

Purpose of the Study:

  • To investigate the association between CRP levels and childhood OSA.
  • To determine the impact of adenotonsillectomy on serum CRP levels in children diagnosed with OSA.

Main Methods:

  • Recruited 326 children with suspected OSA undergoing polysomnography.
  • Measured serum C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) levels before and after adenotonsillectomy for OSA.
  • Analyzed the correlation between apnea-hypopnea index (AHI) and hs-CRP levels.

Main Results:

  • Children with OSA (AHI > 5) exhibited significantly higher hs-CRP levels compared to controls.
  • hs-CRP levels showed a positive correlation with AHI, indicating increased inflammation with OSA severity.
  • Adenotonsillectomy did not significantly alter hs-CRP in all OSA patients but markedly reduced levels in those with initially abnormal hs-CRP (> 1 mg/dL).

Conclusions:

  • Elevated hs-CRP levels are associated with OSA in children.
  • Adenotonsillectomy is an effective treatment for reducing hs-CRP levels in children with OSA and elevated baseline CRP.
Abstract

Keywords:
AdenoidectomyC-Reactive proteinPolysomnographySleep apnea syndromesTonsillectomy

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