[Meningiomas: A review of current knowledge]

Area of Science:

• Neuro-oncology
• Neoplasms
• Central Nervous System (CNS) Tumors

Background:

• Meningiomas are the most common primary intracranial tumors, accounting for over 30% of CNS neoplasms.
• While typically benign and treatable, over 20% exhibit atypical or malignant features, complicating prognosis and treatment.
• Recent advances in understanding meningioma genetics and epigenetics are revealing new therapeutic targets and prognostic markers.

Purpose of the Study:

• To review the current epidemiology, histology, molecular characteristics, diagnosis, and treatment of meningiomas.
• To highlight the association between meningioma development and hormonal factors.
• To incorporate recent recommendations from the French National Drug Safety Agency regarding meningiomas.

Main Methods:

• Literature review of epidemiological, histological, and molecular data on meningiomas.
• Analysis of genetic and epigenetic findings in meningioma research.
• Synthesis of diagnostic and therapeutic strategies, including hormonal influences.

Main Results:

• Identification of meningiomas as frequent CNS tumors with variable behavior.
• Discovery of genetic and epigenetic markers influencing prognosis and treatment.
• Established link between hormonal intake and meningioma development.

Conclusions:

• Understanding the molecular landscape of meningiomas is crucial for improved prognostic evaluation and targeted therapies.
• Hormonal factors play a significant role in meningioma development, necessitating careful consideration in clinical practice.
• This review provides a comprehensive overview for clinicians and researchers managing meningioma patients.