Synergistic and antagonistic antioxidant effects in the binary cannabinoids mixtures

From the group of nearly 120 cannabinoids identified in the hemp sativa and marijuana, CBG, CBD, THC and their acidic forms CBGA, CBDA and THCA are the most frequently studied. All these cannabinoids exhibit antioxidant activity manifested in the ability to scavenge free radicals, to prevent the oxidation process and to reduce metal ions. The paper reports and discusses the antioxidant properties of binary mixtures of the mentioned cannabinoids as regards their ability to scavenge free radicals. The paper shows that, depending on cannabinoid type in their binary mixture and their amounts ratio, an additive, synergistic and antagonistic effect of their antioxidant activity is observed. Binary mixtures of the tested cannabinoids in the full range of their molar ratios were used in the experiments. The presented results seems to be essential in terms of more and more numerous reports showing greater pharmacological effectiveness of binary cannabinoid mixtures compared to that of their individual components.