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Reticulo-endothelial function in obstructive jaundice.

¹Department of Surgery, Royal Surrey County Hospital, Guildford, UK.

The British Journal of Surgery

|December 1, 1987

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Reticulo-endothelial phagocytic function is significantly impaired in obstructive jaundice, correlating with bilirubin levels. This dysfunction, particularly severe with cholangitis, is not explained by reduced blood flow or opsonins.

Area of Science:

Immunology
Gastroenterology
Hepatology

Background:

Obstructive jaundice can impact various physiological functions.
Reticulo-endothelial system (RES) plays a crucial role in immune surveillance and clearance.
Understanding RES function in obstructive jaundice is vital for patient management.

Purpose of the Study:

To investigate reticulo-endothelial (RE) phagocytic function in patients with obstructive jaundice.
To determine the correlation between RE function and clinical/biochemical parameters in jaundice.
To identify factors contributing to RE dysfunction in this patient group.

Main Methods:

Study involved 30 patients with obstructive jaundice and a control group.
RE phagocytic function was assessed using the clearance rate of intravenous human micro-aggregated albumin.

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Correlations were analyzed between phagocytic function and plasma bilirubin, transaminase, bile salt levels, and presence of malignancy or cholangitis.

Main Results:

Significantly depressed RE phagocytic function was observed in jaundiced patients compared to controls (P < 0.001).
A strong correlation was found between phagocytic function and plasma bilirubin levels (P < 0.001).
Phagocytic function was markedly reduced in patients with cholangitis, but not related to malignancy.

Conclusions:

Obstructive jaundice leads to a significant impairment of reticulo-endothelial phagocytic function.
Elevated bilirubin levels are closely associated with this RE dysfunction.
Cholangitis exacerbates RE dysfunction, independent of hepatic blood flow or opsonin levels.