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8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

Gang Xing1, Zhengxing Zhi1, Ce Yi1

  • 1Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.

European Journal of Medicinal Chemistry
|July 17, 2021
PubMed
Summary

New 8-hydroxyquinolin-2(1H)-one analogues, B05 and C08, show potent and selective beta2-agonistic activity. These compounds demonstrate potential as bronchodilators for chronic respiratory diseases.

Keywords:
AsthmaCOPDFormoterolIndacaterolOlodaterolβ(2)-adrenoceptor agonist

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