Related Experiment Video

Updated: Oct 28, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.5K

Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary

Fatih Aksoy1, Hasan Aydın Baş2, Ali Bağcı1

  • 1Suleyman Demirel University, Faculty of Medicine, Cardiology Department, Turkey.

Revista Portuguesa De Cardiologia
|July 18, 2021
PubMed

Insights

Oxidative stress and inflammation markers predict contrast-induced nephropathy (CIN) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI). Higher levels of these markers, along with contrast volume and glucose, increase CIN risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Contrast-induced nephropathy (CIN) is a serious complication following primary percutaneous coronary intervention (p-PCI).
  • Oxidative stress and inflammation are implicated as key factors in CIN development.

Purpose of the Study:

  • To investigate the association between oxidative stress, inflammation markers, and CIN in ST-elevation myocardial infarction (STEMI) patients.
  • To identify predictors of CIN in this patient cohort.

Main Methods:

  • Prospective cohort study involving 341 STEMI patients.
  • Patients were categorized into groups with and without CIN.
  • Multivariate regression analysis was employed to determine CIN predictors.

Main Results:

  • Increased oxidative stress index, high-sensitivity C-reactive protein (hs-CRP), and uric acid (UA) were linked to CIN development.
  • Contrast media volume/glomerular filtration rate (eGFR) ratio and initial glucose levels were also significant predictors.

Conclusions:

  • Elevated oxidative stress and inflammation markers are associated with CIN in STEMI patients.
  • Contrast media volume/eGFR ratio, initial glucose, UA, and hs-CRP are independent predictors of CIN.
Abstract

Keywords:
Contrast-induced nephropathyEnfarte do miocárdio com elevação do segmento STEstados oxidante e antioxidanteNefropatia induzida por contrasteOxidant and antioxidant statusST-segment elevation myocardial infarction

More Related Videos

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.4K
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

6.5K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
54
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
326
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
182
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
65
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
96