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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

993
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Opioid Receptors: Overview01:22

Opioid Receptors: Overview

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Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Related Experiment Video

Updated: Oct 28, 2025

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
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TRPC5 and the path towards analgesic drug development.

Franziska Denk1

  • 1Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, SE1 1UL, UK.

Trends in Neurosciences
|July 18, 2021
PubMed
Summary

Transient receptor potential canonical 5 (TRPC5) shows promise as a novel target for pain relief. This research explores TRPC5

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Chronic pain affects millions globally, necessitating novel therapeutic strategies.
  • The opioid crisis underscores the urgent need for non-addictive analgesics.
  • Transient receptor potential (TRP) channels are implicated in pain signaling pathways.

Purpose of the Study:

  • To investigate the role of transient receptor potential canonical 5 (TRPC5) in pain conditions.
  • To evaluate TRPC5 as a potential therapeutic target for analgesic drug development.

Main Methods:

  • Review of recent findings by Sadler et al. concerning TRPC5.
  • Analysis of TRPC5's function in preclinical pain models (details not provided in abstract).
  • Contextualization within the landscape of current analgesic drug development.
Keywords:
Trp channelschronic painlysophosphatidylcholinereproducibility

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Main Results:

  • Sadler et al. identified TRPC5 as a significant factor in pain pathways.
  • TRPC5 inhibition or modulation emerges as a viable strategy for pain management.

Conclusions:

  • TRPC5 represents a promising molecular target for developing new pain medications.
  • Targeting TRPC5 could offer an alternative to current treatments, addressing the opioid crisis.