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Related Experiment Video

Updated: Oct 28, 2025

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Necrotizing enterocolitis and the gut-lung axis.

Kent A Willis1, Namasivayam Ambalavanan1

  • 1Department of Pediatrics, Division of Neonatology, University of Alabama, Birmingham, United Kingdom.

Seminars in Perinatology
|July 18, 2021
PubMed
Summary
This summary is machine-generated.

The gut-lung axis links gut health to lung health. This review explores how gut issues in premature infants, like necrotizing enterocolitis, increase the risk of lung disease, such as bronchopulmonary dysplasia.

Keywords:
Bronchopulmonary dysplasiaMicrobiomeNecrotizing Enterocolitis

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Area of Science:

  • Microbiology
  • Neonatology
  • Pulmonology

Background:

  • The gut-lung axis describes the bidirectional communication between the gut microbiota and the lungs.
  • Pulmonary and gastrointestinal diseases are often treated in isolation, neglecting their interconnectedness.
  • Necrotizing enterocolitis and bronchopulmonary dysplasia are severe conditions in premature infants affecting the gut and lungs, respectively.

Purpose of the Study:

  • To review the pathophysiology of the gut-lung axis.
  • To highlight the contribution of the gut-lung axis to disease risk in premature infants.
  • To emphasize the link between necrotizing enterocolitis and bronchopulmonary dysplasia.

Main Methods:

  • Literature review of studies on the gut-lung axis.
  • Analysis of the pathophysiology linking gut and lung diseases in neonates.
  • Synthesis of evidence on necrotizing enterocolitis and bronchopulmonary dysplasia.

Main Results:

  • The gut microbiota significantly influences lung development and disease.
  • Gut inflammation and dysbiosis can exacerbate lung injury.
  • Premature infants with necrotizing enterocolitis show increased susceptibility to bronchopulmonary dysplasia.

Conclusions:

  • The gut-lung axis is a critical factor in neonatal health and disease.
  • Understanding this axis can lead to integrated treatment strategies for premature infants.
  • Targeting the gut microbiota may offer novel therapeutic approaches for bronchopulmonary dysplasia.