A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity

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Brendan Le Daré1, Pierre-Jean Ferron2, Nessrine Bellamri2

  • 1Pharmacy, Pontchaillou University Hospital, F-35000, Rennes, France; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France.

Toxicon : Official Journal of the International Society on Toxinology
|July 18, 2021
PubMed

Insights

Marine worm hemoglobin (M101) may reduce liver damage caused by toxic mushroom compounds (amanitins). This finding suggests M101’s potential as a therapeutic agent for amanitin poisoning.

Area of Science:

  • Toxicology
  • Biochemistry
  • Pharmacology

Background:

  • Amanitins, bicyclic octapeptides from certain mushrooms, cause severe, potentially lethal hepatotoxicity.
  • M101, an extracellular hemoglobin from Arenicola marina, functions as an oxygen carrier and possesses Cu/Zn-SOD-like activity.

Purpose of the Study:

  • To investigate the potential of M101 in mitigating amanitin-induced hepatotoxicity.
  • To explore M101's therapeutic potential for treating mushroom poisoning.

Main Methods:

  • The study evaluated the effects of M101 on liver toxicity induced by amanitins.
  • Assays were performed to assess M101's protective mechanisms against cellular damage.

Main Results:

  • Preliminary results indicate that M101 demonstrates efficacy in reducing amanitin-induced liver damage.
  • M101's intrinsic Cu/Zn-SOD-like activity may contribute to its protective effects.

Conclusions:

  • M101 shows promise as a potential therapeutic agent for amanitin poisoning.
  • Further research is warranted to fully elucidate M101's mechanism of action and therapeutic utility.
Keywords:
AmanitinHepatocyteHepatotoxicityM101Oxygen carrier

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