Related Experiment Video
Updated: Oct 28, 2025
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
2.2K
Correction of overactive bladder with botulinum toxin type A (BTX-A)
Andrey Grishin1, Anastasiya Spaska2, Lyailya Kayumova1
1I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Summary
Botulinum toxin type A (BTX-A) injections effectively treat overactive bladder symptoms by reducing involuntary detrusor contractions. This treatment improves bladder function and patient quality of life, offering a safe alternative when drug therapy fails.
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder (OAB) is a common condition characterized by involuntary detrusor muscle contractions.
- Current drug therapies for OAB have limited duration due to side effects.
Purpose of the Study:
- To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) for treating overactive bladder.
- To assess BTX-A's impact on clinical symptoms, bladder capacity, and quality of life in OAB patients.
Main Methods:
- A study involving 90 patients with overactive bladder, divided into two groups based on the presence of imperative urinary incontinence.
- Intravesical injection of 200 units of botulinum toxin type A (Xeomin) was administered to all participants.
Main Results:
- BTX-A treatment significantly reduced clinical symptoms associated with overactive bladder.
- The functional volume of the bladder increased post-treatment.
- Patients reported an improved quality of life following BTX-A injections.
Conclusions:
- Botulinum toxin type A is an effective and safe treatment for patients with overactive bladder, particularly those unresponsive to anticholinergic medications.
- BTX-A offers a viable therapeutic option for managing overactive bladder dysfunction and improving patient outcomes.
Related Concept Videos
01:23Urinary Bladder
1.9K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.9K
01:26The Micturition Reflex
1.3K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
1.3K
01:30Urinary Tract Calculi III: Medical Management
60
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
60
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
448
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
448
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
861
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
861
01:25Urinary Tract Calculi VI: Surgical Management
78
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
78