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gamma-Aminobutyric acid (GABA) uptake systems in human frontal cortex
H S Sidhu1, D G Munoz, J D Wood
1Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
Brain Research
|December 1, 1987
Abstract:
Synaptosomes prepared from human frontal cortex possessed two uptake systems for gamma-aminobutyric acid (GABA) with Km values of 1.9 and 20.6 microM respectively, and with Vmax values of 0.15 and 0.78 nmol/min/mg protein respectively. In this respect, human tissue preparations differed from cortical synaptosomes from rodents in that a third, low-affinity GABA uptake system was not detectable in human synaptosomes.