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Updated: Oct 28, 2025

Author Spotlight: Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy
Published on: May 12, 2023
Single-atom nanozymes and environmental catalysis: A perspective.
Vishal Kandathil1, Siddappa A Patil1
1Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore 562112, India.
Single-Atom Nanozymes (SANs) offer enhanced activity and specificity by evenly distributing active sites on solid supports. This review explores SANs
Area of Science:
- Nanomaterials Science
- Catalysis
- Biotechnology
Background:
- Nanozymes exhibit intrinsic enzyme-like activity, attracting significant research interest.
- The field of artificial enzymes is rapidly evolving with novel designs.
- Challenges in nanozyme specificity and activity stem from irregular active site distribution.
Purpose of the Study:
- To provide an overview of Single-Atom Nanozymes (SANs) architecture, synthesis, and applications.
- To highlight the potential of SANs in environmental catalysis.
- To discuss the future challenges and prospects of SANs.
Main Methods:
- Review of existing literature on nanozyme and SAN development.
- Analysis of SANs' structural advantages over traditional nanozymes.
- Exploration of SANs' catalytic mechanisms and performance.
Main Results:
- SANs demonstrate high activity and specificity due to uniform active site distribution.
- SANs combine benefits of homogeneous (activity) and heterogeneous (recyclability) catalysts.
- SANs show promise for various applications, including environmental catalysis.
Conclusions:
- SANs represent a significant advancement in artificial enzyme technology.
- Evenly distributed active sites in SANs overcome limitations of traditional nanozymes.
- Further research into SANs' design and applications, particularly in environmental catalysis, is warranted.
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