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Published on: December 9, 2016
Eribulin induces tumor vascular remodeling through intussusceptive angiogenesis in a sarcoma xenograft model
Eiko Taguchi1, Keisuke Horiuchi2, Akira Senoo3
1Department of Orthopedic Surgery, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, 359-8513, Japan.
Abstract:
Eribulin is a novel microtubule inhibitor that, similar to other types of microtubule inhibitors, induces apoptosis by inhibiting the mitotic division of cells. Besides this direct effect on tumor cells, previous studies have shown that eribulin has the potential to induce tumor vascular remodeling in several different cancers; however, the mechanisms underlying this phenomenon remain unclear. In the present study, we aimed to elucidate whether eribulin is effective against synovial sarcoma, a relatively rare sarcoma that often affects adolescents and young adults, and to histologically investigate the microstructure of tumor vessels after the administration of eribulin. We found that eribulin exhibits potent antitumor activity against synovial sarcoma in a tumor xenograft model and that tumor vessels frequently have intervascular pillars, a hallmark of intussusceptive angiogenesis (IA), after the administration of eribulin. IA is a distinct form of angiogenesis that is involved in normal developmental processes as well as pathological conditions. Our data indicate that IA is potentially involved in eribulin-induced vascular remodeling and thereby suggest previously unacknowledged role of IA in regulating the tumor vasculature after eribulin administration.
Insights
Eribulin shows strong anti-cancer effects against synovial sarcoma by promoting intussusceptive angiogenesis (IA), a unique blood vessel formation process. This study highlights IA
Area of Science:
- Oncology
- Cancer Biology
- Angiogenesis Research
Background:
- Eribulin is a microtubule inhibitor that induces apoptosis and has shown potential for tumor vascular remodeling in various cancers.
- The precise mechanisms behind eribulin's vascular remodeling effects remain unclear.
- Synovial sarcoma is a rare cancer predominantly affecting adolescents and young adults.
Purpose of the Study:
- To evaluate the efficacy of eribulin against synovial sarcoma.
- To investigate the histological changes in tumor vasculature following eribulin administration.
- To explore the role of intussusceptive angiogenesis (IA) in eribulin's effects.
Main Methods:
- Utilized a tumor xenograft model to assess eribulin's antitumor activity in synovial sarcoma.
- Conducted histological examination of tumor microvasculature post-eribulin treatment.
- Analyzed the presence of intervascular pillars as indicators of intussusceptive angiogenesis.
Main Results:
- Eribulin demonstrated potent antitumor activity against synovial sarcoma in the xenograft model.
- Tumor vessels in treated samples frequently exhibited intervascular pillars, characteristic of intussusceptive angiogenesis (IA).
- These findings suggest IA is involved in eribulin-induced vascular remodeling.
Conclusions:
- Eribulin is effective against synovial sarcoma, exhibiting significant antitumor effects.
- The study identifies intussusceptive angiogenesis (IA) as a key mechanism in eribulin-mediated vascular remodeling.
- This research uncovers a novel role for IA in regulating tumor vasculature after eribulin treatment.
