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Effects of low-dose oxygen administration on renal blood oxygenation level-dependent MRI in children with

Tomohiko Nishino1, Kazuhiro Takahashi2, Sayaka Ono2

  • 1Department of Pediatrics, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. sinonosino@yahoo.co.jp.

Magma (New York, N.Y.)
|July 18, 2021
PubMed

Insights

Low-dose oxygen administration impacts renal blood oxygenation level-dependent (BOLD) MRI results in children. This effect varies between healthy kidneys and those with glomerulonephritis, influencing disease monitoring.

Area of Science:

  • Pediatric Radiology
  • Nephrology
  • Medical Imaging

Background:

  • Children often require sedation for renal MRI, sometimes with supplemental oxygen.
  • The impact of low-dose oxygen on renal BOLD MRI findings is not well understood.
  • Renal disease assessment using BOLD MRI may be influenced by oxygen administration.

Purpose of the Study:

  • To investigate the effect of low-dose oxygen on renal BOLD MRI in children.
  • To determine if this effect differs in the presence or absence of renal disease, specifically glomerulonephritis.

Main Methods:

  • Retrospective analysis of pediatric renal MRI scans (2013-2020).
  • Patients categorized into glomerulonephritis and non-glomerulonephritis groups.
  • Renal spin relaxation time (T2*) measured using 3.0T MRI.

Main Results:

  • Oxygen administration significantly reduced the mean R2* value in the medulla across all patients.
  • The non-glomerulonephritis group showed a decrease in mean R2* with oxygen, unlike the glomerulonephritis group.
  • Significant differences in oxygen response were observed between groups in both cortex and medulla.

Conclusions:

  • Low-dose oxygen administration demonstrably alters renal BOLD MRI results.
  • Understanding these oxygen-induced fluctuations is crucial for accurate BOLD MRI interpretation.
  • This knowledge may aid in monitoring disease activity in pediatric glomerulonephritis.
Abstract

Keywords:
Blood oxygenation level-dependentGlomerulonephritisMagnetic resonance imagingOxygen administrationPediatric

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