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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Autoimmune encephalitis in a tertiary hospital in the Philippines

Nikolai Gil D Reyes1, Adrian I Espiritu2, Jerson F Agabao3

  • 1Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|July 19, 2021
PubMed

Insights

Autoimmune encephalitis (AE) presents diverse symptoms in adults and children, with anti-NMDAR encephalitis being common. Early intervention improves outcomes, particularly in pediatric cases, despite limited diagnostic lab support.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Autoimmune encephalitis (AE) is an emerging neurological disorder affecting both adults and children.
  • Prompt diagnosis and treatment are crucial due to AE's potentially reversible nature.

Purpose of the Study:

  • To characterize the clinical and paraclinical features of AE patients.
  • To evaluate treatment outcomes in a Philippine tertiary hospital setting.

Main Methods:

  • Retrospective case series design.
  • Inclusion of patients with definite autoimmune encephalitis.

Main Results:

  • Eighteen patients (12 adults, 6 children) with a majority of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis.
  • Common presentations included psychiatric symptoms and seizures; imaging was often normal. CSF pleocytosis and protein elevation showed variable results.
  • High-dose steroids and IVIG were common treatments, with 66.7% overall improved outcomes, especially in children.

Conclusions:

  • AE exhibits a broad clinical spectrum with shared and distinct features in adults and children.
  • Laboratory investigations offer supportive but limited diagnostic value for AE.
  • Early intervention is vital for AE management, influencing treatment and outcomes in the local context.
Abstract

Keywords:
Autoimmune encephalitisClinical featuresOutcomePhilippinesTreatment

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