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Burn-Induced Cardiac Dysfunction: A Brief Review and Long-Term Consequences for Cardiologists in Clinical Practice

Veronika Krbcová Moudrá1, Robert Zajíček2, Bohumil Bakalář2

  • 1Third Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Cardiology, University Hospital Kralovske Vinohrady, Prague, Czech Republic.

Heart, Lung & Circulation
|July 19, 2021
PubMed

Insights

Severe burn injury triggers long-term stress responses that can lead to heart disease, impacting patient survival and quality of life. Understanding these chronic cardiac changes is crucial for better treatment.

Area of Science:

  • Cardiovascular Science
  • Trauma Medicine
  • Burn Injury Research

Background:

  • Severe burn injury induces prolonged hypermetabolic and stress responses.
  • These responses involve increased stress hormones and proinflammatory cytokines.
  • Persisting responses can lead to long-term complications, including myocardial dysfunction.

Purpose of the Study:

  • To review the mechanisms of late cardiovascular dysfunction after severe burn injury.
  • To highlight the impact of burn-induced heart disease on patient outcomes.
  • To emphasize the need for understanding chronic cardiovascular changes.

Main Methods:

  • Literature search of major scientific databases (PubMed, ScienceDirect, NIH, Google Scholar).
  • Compilation of studies focusing on late cardiovascular complications post-burn.
  • Keyword-based search for relevant research articles.

Main Results:

  • Burn-induced heart disease is a significant factor in morbidity and mortality.
  • It contributes to a reduced quality of life for burn survivors.
  • Mechanisms of myocardial dysfunction are partially understood, with limited knowledge of chronic cardiovascular changes.

Conclusions:

  • A comprehensive understanding of chronic cardiac pathophysiology post-burn is essential.
  • This knowledge can inform preventive treatment strategies.
  • Improved understanding aims to enhance long-term outcomes for burn patients.
Abstract

Keywords:
Burn injuryHeart failureHypermetabolismMyocardial dysfunctionProinflammatory cytokines

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