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Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake

Masayuki Aiba1, Yutaka Tsutsumi1, Jun Nagai1

  • 1Department of Hematology, Hakodate Municipal Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|July 19, 2021
PubMed

A 71-year-old woman was admitted for the treatment of diffuse large B-cell lymphoma of the ileum. She had been taking lansoprazole but was switched to vonoprazan due to epigastric discomfort. Three weeks after starting vonoprazan intake, she had a convulsive seizure, and a blood test showed hypomagnesiemia. The cause of hypomagnesemia was considered to be malabsorption of magnesium from the intestinal tract associated with vonoprazan. After discontinuation of vonoprazan, the magnesium level quickly recovered, and the seizures did not relapse. It is important to consider the risk of hypomagnesemia in patients taking vonoprazan, even for a short period of time.

Keywords:
hypomagnesemiaproton-pomp inhibitorseizurevonoprazan

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