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Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery
Akihiro Sasaki1,2, Tatsuya Kato2, Hideki Ujiie2
1Department of Surgery, Obihiro Kosei General Hospital, Obihiro, Hokkaido, Japan.
Introduction:
Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery.
Presentation Of Case:
A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months.
Conclusion:
Surgical treatment would be effective for patients with SPS and thymoma.
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