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Updated: Oct 28, 2025
Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Relationship Between Myocardial Perfusion and Myocardial Function in Dilated Cardiomyopathy by Shown Ultrasonography
Juan Ma1, Lina Guan1, Lingjie Yang1
1Department of Echocardiography, First Affiliated Hospital of Xinjiang Medical University.
Insights
Dilated cardiomyopathy (DCM) patients show reduced myocardial perfusion and impaired systolic function. Myocardial perfusion is positively correlated with myocardial mechanics, highlighting its importance in DCM.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
- Assessing left ventricular myocardial microcirculation and systolic function is crucial for DCM diagnosis and management.
- Current diagnostic methods may not fully capture the intricate relationship between perfusion and mechanics in DCM.
Purpose of the Study:
- To evaluate left ventricular myocardial microcirculation perfusion and systolic function in DCM patients using MCE and 2D-STE.
- To explore the correlation between myocardial perfusion and myocardial strain parameters in DCM.
- To provide insights into the pathophysiology of DCM by linking perfusion deficits to mechanical dysfunction.
Main Methods:
- Conventional ultrasound, myocardial contrast echocardiography (MCE), and 2D speckle tracking echocardiography (2D-STE) were performed on 30 DCM patients and 30 controls.
- Analysis included left ventricular microcirculation perfusion parameters (e.g., rising slope A, peak intensity PI, area under the curve AUC) and myocardial strain parameters (global longitudinal strain GLS, global circumferential strain GCS).
- Correlation analysis was used to determine the relationship between perfusion and strain parameters.
Main Results:
- DCM patients exhibited significantly reduced regional myocardial perfusion compared to controls (P < 0.05).
- Left ventricular systolic function, including GLS and GCS, was significantly impaired in DCM patients (P < 0.001).
- Positive correlations were found between mitral valve A and GCS, and between MV-E/e' and AUC of basal/intermediate segments, indicating a link between perfusion and mechanics.
Conclusions:
- Regional myocardial microcirculation perfusion is reduced in DCM.
- Myocardial strain and systolic function are impaired in DCM patients.
- Myocardial perfusion demonstrates a significant positive correlation with myocardial mechanics in DCM, suggesting its role in disease progression.
Abstract:
Myocardial contrast echocardiography (MCE) and two-dimensional speckle tracking echocardiography (2D-STE) were used to detect left ventricular myocardial microcirculation perfusion and myocardial systolic function in dilated cardiomyopathy (DCM) and to explore the relationship between the two.Conventional ultrasound, MCE, and 2D-STE examinations were performed on 30 patients and 30 controls. Left ventricular microcirculation perfusion, left ventricular longitudinal strain (GLS), and circumferential strain (GCS) were analyzed to further compare the correlation between left ventricular perfusion and myocardial strain parameters.Regional myocardial perfusion was reduced in patients with DCM, manifesting as a decrease in the rising slope (A) of the mid-segment of the posterior septum, the peak intensity (PI) of the mid-segment of the anterior septum and the posterior septum, the apical segment of the lateral wall, the area under the curve (AUC) of the posterior septum, the basal segment of the posterior wall, the anterior septum, posterior septum, posterior wall, mid-segment of the lateral wall, and apical segment of the lateral wall and the overall average PI and AUC of the mid-segment, compared with that in the controls (P < 0.05). The left ventricular systolic function and the strain parameters GLS and GCS of DCM patients were lower than those of the controls (P < 0.001). Correlation analysis revealed a positive correlation between the A of the mitral valve and GCS (r = 0.372, P = 0.043), and MV-E/e' had a positive correlation with the AUC of the basal and intermediate segments (r = 0.379, P = 0.039; r = 0.404, P = 0.027).In patients with DCM, regional myocardial microcirculation perfusion is reduced, and myocardial strain is impaired. Myocardial perfusion has a good positive correlation with myocardial mechanics.
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