Regulation of recovery in the erythroid lineage: model studies

Based on data from the literature, the major regulatory features were established for the erythroid population regenerating after perturbation. A mathematical model is proposed which takes into account: (1) the increase in the proliferating CFU-S due to depopulation of CFU-S and BFU-E/8 pools due to increased migration caused by erythropoietin; (2) regeneration of erythroid precursors due to short-range factors and (3) gradual reduction in the short-range effects and increase in the humoral influence on BFU-E/8, BFU-E/3 and CFU-E together with short-range suppression of progenitor differentiation and acceleration of maturation in all subpopulations due to humoral factors. The kinetics of subpopulations as a function of feedback and maturation rate are analysed. The dependence of erythrocyte production on erythrocyte depletion in the blood and on the feedback coefficient is defined.