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Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy.

Lucía Cárcel1, Luis G De la Casa1

  • 1Laboratory of Animal Behavior and Neuroscience, Department of Experimental Psychology, University of Seville, Seville, Spain.

Frontiers in Behavioral Neuroscience
|July 19, 2021
PubMed
Summary

Repeated context and haloperidol pairings create conditioned catalepsy. Longer pairings and shorter intervals between drug exposure and context presentation intensify this Pavlovian response.

Keywords:
catalepsyclassical conditioninghaloperidolinter stimulus intervalsimultaneous conditioning

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Area of Science:

  • Neuroscience
  • Behavioral Psychology
  • Pharmacology

Background:

  • Context-dependent catalepsy can be conditioned using antipsychotic drugs like haloperidol.
  • Pavlovian conditioning principles are hypothesized to underlie this phenomenon.

Purpose of the Study:

  • To investigate the role of Pavlovian processes in context-dependent catalepsy.
  • To examine how conditioning intensity manipulations affect haloperidol-induced conditioned catalepsy.

Main Methods:

  • Two experiments were conducted manipulating the duration of context-drug pairings and the inter-stimulus interval (ISI).
  • Conditioned catalepsy was measured in a drug-free state following conditioning trials.

Main Results:

  • Increased duration of context-haloperidol pairings enhanced conditioned catalepsy.
  • A reduced ISI between drug administration and context exposure also increased conditioned catalepsy.

Conclusions:

  • The findings support the involvement of Pavlovian conditioning in context-dependent catalepsy.
  • Temporal parameters of conditioning, particularly ISI, significantly influence drug-associated conditioned responses.