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The Role of C-reactive Protein in Patient Risk Stratification and Treatment

Ramón Arroyo-Espliguero1, María C Viana-Llamas1, Alberto Silva-Obregón2

  • 1Department of Cardiology, Hospital Universitario de Guadalajara Guadalajara, Spain.

European Cardiology
|July 19, 2021
PubMed

Insights

Inflammation plays a key role in atherosclerosis. C-reactive protein is a valuable biomarker for assessing cardiovascular risk and guiding treatment decisions in high-risk patients.

Area of Science:

  • Cardiology
  • Inflammation Biology
  • Biomarker Research

Background:

  • Atherosclerosis is a chronic inflammatory condition.
  • Circulating inflammatory markers can predict cardiovascular events and identify high-risk individuals.
  • New therapeutic targets are needed to reduce residual cardiovascular risk in coronary artery disease patients.

Purpose of the Study:

  • To review the role of C-reactive protein (CRP) as an inflammatory biomarker in cardiovascular risk stratification.
  • To discuss the concept of residual risk in cardiovascular prevention.
  • To examine current international guideline recommendations on using inflammatory biomarkers for risk assessment.

Main Methods:

  • Literature review of studies on C-reactive protein and cardiovascular events.
  • Analysis of the concept of residual cardiovascular risk.
  • Synthesis of current international guidelines on cardiovascular risk stratification.

Main Results:

  • C-reactive protein is the most studied inflammatory biomarker for cardiovascular risk.
  • Reducing inflammation with therapies like canakinumab and colchicine shows clinical benefits.
  • Inflammation is a key aetiopathogenic mechanism in atherosclerosis.

Conclusions:

  • C-reactive protein is a significant biomarker for cardiovascular risk stratification.
  • Addressing residual risk through inflammation modulation is a promising therapeutic strategy.
  • Further research and guideline updates are needed to optimize the use of inflammatory biomarkers in clinical practice.

Keywords:
C-reactive proteinInflammationcoronary artery diseaseprimary preventionsecondary prevention

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