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Does Baseline Diuretics Use Affect Prognosis in Patients With COVID-19?

Nirmal Guragai1, Rahul Vasudev1, Kevin Hosein1

  • 1Cardiology, St Joseph University Medical Center, Paterson, USA.

Cureus
|July 19, 2021
PubMed

Insights

Prior use of diuretics did not impact COVID-19 patient outcomes. This study found no significant difference in mortality or illness severity after adjusting for confounding factors in coronavirus disease 2019 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic presents a global healthcare challenge.
  • Previous research explored angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in COVID-19.
  • The impact of prior diuretic use on COVID-19 patient mortality was previously unknown.

Purpose of the Study:

  • To investigate the effect of baseline diuretic use on mortality and illness severity in hospitalized COVID-19 patients.
  • To analyze the association between diuretic use and in-hospital survival rates for coronavirus disease 2019.

Main Methods:

  • Retrospective study conducted in three Northern New Jersey hospitals from March 15, 2020, to April 30, 2020.
  • Included 313 patients admitted with COVID-19, comparing outcomes between those taking diuretics and those not.
  • Primary outcome: in-hospital mortality; Secondary outcome: COVID-19 illness severity.

Main Results:

  • Unadjusted analysis showed higher mortality (57.35% vs 37.96%) and severe illness (79.41% vs 47.35%) in patients taking diuretics.
  • After adjusting for confounding factors, no significant difference in mortality or severity was observed between the groups.
  • The p-value for mortality difference was 0.0042, and for severe illness was <.0001 in unadjusted analysis.

Conclusions:

  • Baseline use of diuretics has no discernible effect on the prognosis of COVID-19.
  • The study suggests that diuretics do not influence mortality or severity in patients admitted with coronavirus disease 2019.
  • Further research may be warranted to confirm these findings in diverse patient populations.

Keywords:
ace inhibitors and angiotensin receptor blockersanticoagulationcoronavirus disease 2019 (covid-19)diureticsmortalityseverity

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