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Comparison of Iron Profile in Patients With and Without Coronary Heart Disease

Zain Amar1, Abdul Subhan Talpur2, Shumaila Zafar3

  • 1Internal Medicine, Isra University, Hyderabad, PAK.

Cureus
|July 19, 2021
PubMed

Insights

Elevated serum ferritin levels are strongly associated with coronary artery disease (CAD). Managing high ferritin may reduce the risk of developing CAD.

Area of Science:

  • Cardiology
  • Biochemistry
  • Internal Medicine

Background:

  • Atherosclerosis, a primary cause of coronary artery disease (CAD), involves low-density lipoprotein (LDL) oxidation within macrophages.
  • Ferritin and iron possess pro-oxidant properties, with ferritin independently predicting oxidized LDL levels.

Purpose of the Study:

  • To investigate the association between serum ferritin and iron levels and the prevalence of coronary artery disease (CAD).

Main Methods:

  • A case-control study involving 400 CAD patients and 400 controls was conducted.
  • Serum ferritin, serum iron, and total iron-binding capacity (TIBC) were measured and compared between groups.

Main Results:

  • Patients with CAD exhibited significantly higher serum ferritin levels (921.21 ± 201.21 ug/L) compared to controls (101.21 ± 92.21 ug/L; p<0.0001).
  • Serum TIBC was significantly lower in the CAD group (302.12 ± 101.75 umol/L) versus the control group (362.12 ± 82.16 umol/L).

Conclusions:

  • Higher ferritin levels indicate an increased risk for CAD.
  • Consulting a physician for ferritin level management, potentially through lifestyle changes or medication, is recommended to mitigate CAD risk.

Keywords:
associationcoronary artery diseaseferritinironoxidized low density lipoproteinserum iron level

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