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Demographic Pattern and Mortality Risk Factors for Prescription Opioid Overdose Hospitalizations: Results From
Albulena Sejdiu1, Kristal N Pereira2, Hajara Joundi3
1Psychiatry, Saints Cyril and Methodius University, Skopje, MKD.
Cureus
|July 19, 2021
Summary
Hospitalizations for prescription opioid overdose (POD) disproportionately affect older white females from lower incomes. Medical complications, not substance use disorders, significantly increase mortality risk in POD patients.
Area of Science:
- Public Health
- Epidemiology
- Clinical Medicine
Background:
- Prescription opioid overdose (POD) is a growing public health concern.
- Understanding the demographics and risk factors for POD hospitalizations is crucial for targeted interventions.
Purpose of the Study:
- To identify demographic patterns of hospitalizations related to prescription opioid overdose (POD).
- To evaluate the mortality risk associated with comorbidities in POD inpatients.
Main Methods:
- A cross-sectional study utilizing the Nationwide Inpatient Sample (NIS) database.
- Inclusion of 184,711 patients hospitalized for POD.
- Binomial logistic regression analysis to assess mortality risk (Odds Ratio) for comorbidities.
Main Results:
- POD hospitalizations were most common among females (54.1%), older adults aged 51-75 (48.5%), whites (81.5%), and those in lower income quartiles (32.8%).
- Prevalent substance use disorders (SUD) included alcohol (15.7%), cannabis (5.7%), and cocaine (4.2%).
- Medical complications like cardiac arrest (OR=103.4), shock (OR=15.4), coma (OR=13.4), and respiratory failure (OR=12.1) significantly increased mortality risk.
Conclusions:
- Prescription opioid overdose hospitalizations are more prevalent in specific demographic groups: females, older adults, whites, and lower-income individuals.
- Medical complications pose a substantially higher mortality risk in POD patients compared to comorbid substance use disorders.
- The continued prevalence of prescription opioid use and related hospitalizations underscores its significance as a public health issue.
Keywords:
mortalityopioid use disordersoverdose preventionprescription opioidrisk factorssubstance recreational useMore Related Videos
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