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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Oct 28, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Peptide-Enabled Targeted Delivery Systems for Therapeutic Applications.

Mingpeng Liu1,2,3, Xiaocui Fang1,3, Yanlian Yang1,3

  • 1CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China.

Frontiers in Bioengineering and Biotechnology
|July 19, 2021
PubMed
Summary

Receptor-targeting peptides enhance drug delivery specificity in cancer chemotherapy. Combining these peptides with nanostructures improves drug accumulation and therapeutic efficacy.

Keywords:
drug deliveryenhanced receptor-specificitynanostructuretargeting peptidetumor therapy

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Receptor-targeting peptides are crucial for specific drug delivery in cancer treatment.
  • Peptide-functionalized nanostructures offer high specificity, biocompatibility, and availability for biomedical applications.
  • Developing active targeting systems by linking ligands to drug-loaded nanocarriers is a key strategy.

Purpose of the Study:

  • To review strategies for enhancing receptor-specificity of drug-loaded nanostructures using peptide ligands.
  • To explore the use of peptides targeting tumor-related receptors for improved chemotherapy.
  • To highlight the synergistic potential of nanostructures and receptor-targeting peptides in cancer therapy.

Main Methods:

  • Reviewing various strategies for improving receptor-specificity of nanostructures.
  • Utilizing peptide ligands that target tumor-specific receptors.
  • Chemically linking ligands to drug-loaded nanocarriers to create active targeting systems.

Main Results:

  • Peptide-functionalized nanostructures demonstrate significant potential in drug delivery, imaging, and targeted therapies.
  • Strategies exist to improve the receptor-specificity of nanocarriers using peptide ligands.
  • The combination of nanostructures and receptor-targeting peptides can enhance biofunctions.

Conclusions:

  • The synergism between nanostructures and receptor-targeting peptides can significantly improve drug delivery and therapeutic outcomes in cancer.
  • Peptide-based targeting offers a promising avenue for developing more effective and specific cancer chemotherapy.
  • Further research into these combined strategies could lead to novel therapeutic approaches.