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The Roles of circMTO1 in Cancer

Wei Liu1, Yuanyuan Xiong1, Renhua Wan1

  • 1Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Cell and Developmental Biology
|July 19, 2021
PubMed

Insights

Circular RNA mitochondrial tRNA translation optimization 1 (circMTO1) plays a key role in various cancers. This review details circMTO1

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are novel non-coding RNAs with diverse cellular functions.
  • circRNAs can act as oncogenes or tumor suppressors based on cellular context.
  • circRNA mitochondrial tRNA translation optimization 1 (circMTO1) is implicated in various malignancies.

Purpose of the Study:

  • To review the biological characteristics, functions, and molecular mechanisms of circMTO1.
  • To summarize the roles of circMTO1 in cancer initiation and progression.
  • To discuss future research directions for circMTO1 in oncology.

Main Methods:

  • Literature review of studies on circMTO1.
  • Analysis of circMTO1 expression patterns in different cancers.
  • Investigation of molecular mechanisms underlying circMTO1's function.

Main Results:

  • circMTO1 is abnormally expressed in hepatocellular carcinoma, gastric cancer, and colorectal cancer.
  • circMTO1 contributes to tumor initiation and progression.
  • Specific molecular mechanisms of circMTO1 in cancer are elucidated.

Conclusions:

  • circMTO1 is a significant factor in cancer development.
  • Understanding circMTO1's roles offers potential therapeutic strategies.
  • Further research is warranted to explore circMTO1's full potential in cancer treatment.
Keywords:
cancerscircMTO1circular RNAsmicroRNAtumor progression

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