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Endothelial-Myocardial Angiocrine Signaling in Heart Development

Hyeonyu Kim1,2, Mingqiang Wang1,2, David T Paik1,2

  • 1Stanford Cardiovascular Institute, Stanford University, Stanford, CA, United States.

Frontiers in Cell and Developmental Biology
|July 19, 2021
PubMed

Insights

This review explores diverse cardiac endothelial cell populations and their roles in heart development. Single-cell sequencing reveals how these cells communicate via angiocrine pathways to form heart structures.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Vascular endothelial cells exhibit organ-specific functions and structures.
  • Cardiac endothelial cells are crucial for heart development, utilizing unique angiocrine signaling pathways.
  • Intercellular communication in the developing heart is increasingly understood through advanced techniques.

Purpose of the Study:

  • To review subpopulations of endothelial cells in the mammalian heart.
  • To elucidate the role of angiocrine signaling in cardiac development.
  • To highlight the contribution of heterogeneous cardiac endothelial cells to heart formation.

Main Methods:

  • Review of existing literature on cardiac endothelial cells.
  • Focus on single-cell sequencing data for intercellular communication analysis.
  • Examination of angiocrine pathways in heart development.

Main Results:

  • Cardiac endothelial cells display significant heterogeneity.
  • Specific endothelial subpopulations spatiotemporally regulate heart development.
  • Angiocrine pathways are critical for heart tube, chamber, trabeculation, compaction, and valve formation.

Conclusions:

  • Cardiac endothelial cells are diverse and essential for proper heart development.
  • Angiocrine signaling mediated by endothelial cells is a key mechanism in forming cardiac structures.
  • Single-cell sequencing is a powerful tool for understanding cardiac cell communication and development.

Keywords:
cardiac developmentcardiomyocyteendothelial cellmyocardial compactionsingle-cell sequencing

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