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Updated: Oct 28, 2025

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
Published on: June 13, 2025
Aleem Azal Ali1, Sonal Jadeja2, Neha Agrawal2
1Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida.
This case report describes a patient with esophageal varices that were causing active bleeding. During an endoscopy, the doctors found multiple varices in different parts of the esophagus. Some of these varices were not bleeding, while others showed signs of recent or active bleeding, such as red wale signs and a white nipple sign. The doctors performed a procedure called variceal banding ligation to stop the bleeding. This treatment was successful, and the patient did not experience any further bleeding. The findings suggest that endoscopic evaluation is important for identifying mixed variceal signs and that banding ligation can be an effective treatment in complex cases.
Area of Science:
Background:
Bleeding from esophageal varices remains a critical clinical challenge. Prior research has shown that varices are often classified by size and location, with grade 2 and grade 3 varices posing higher risk for rupture. Established knowledge includes the use of endoscopic band ligation to control bleeding. However, uncertainty remains about optimal management in cases with multiple variceal columns and mixed bleeding signs. No prior work had resolved how to manage concurrent nonbleeding and bleeding varices in the same column. This gap motivated the need for detailed case documentation. Understanding variceal behavior in complex presentations is essential for refining treatment strategies. The presence of red wale signs and white nipple signs indicates active bleeding risk. Yet, the interplay between these signs and nonbleeding varices is not fully understood.
Purpose Of The Study:
This case report aimed to document the endoscopic findings and management of active bleeding from downhill varices. The specific problem addressed was the coexistence of nonbleeding and bleeding varices in the same column. The study's motivation was to clarify how such presentations should be managed. The authors sought to demonstrate the effectiveness of variceal banding ligation in this context. By describing the endoscopic appearance and treatment outcome, the authors hoped to contribute to clinical decision-making. The case involved a patient with multiple variceal columns and stigmata of recent bleeding. The goal was to show that successful ligation is possible even in complex cases. The authors emphasize the importance of recognizing mixed variceal signs during endoscopy.
Main Methods:
The researchers performed an esophagogastroduodenoscopy (EGD) to assess the varices. They documented the location, size, and appearance of the varices using video imaging. The endoscopic findings included grade 2 and grade 3 varices in different esophageal regions. The presence of red wale signs and a white nipple sign was noted as indicators of recent or active bleeding. The team used variceal banding ligation as the primary intervention. No additional therapies were described in the abstract. The procedure was performed on the identified variceal columns. The outcome was monitored for recurrence of bleeding.
Main Results:
The EGD revealed one column of nonbleeding grade 2 varices in the middle third of the esophagus. Three columns of nonbleeding grade 3 varices were found in the upper third of the esophagus. Stigmata of recent bleeding were observed, including red wale signs and a white nipple sign. The variceal banding ligation was successfully performed on the affected columns. No recurrence of bleeding was reported following the procedure. The absence of red wale signs in the nonbleeding varices suggested lower risk. The presence of red wale signs in the bleeding varices indicated higher risk. The treatment outcome supports the use of banding ligation in complex variceal presentations.
Conclusions:
The authors concluded that variceal banding ligation is effective in managing active bleeding from downhill varices. The presence of red wale signs and white nipple signs indicates active bleeding risk. Nonbleeding varices in the same column may not require immediate intervention. The authors propose that successful ligation can prevent recurrence in complex cases. The findings suggest that endoscopic assessment is crucial for identifying mixed variceal signs. The study supports the use of banding ligation as a first-line treatment. No essential role was assigned to additional therapies in this case. The authors emphasize the importance of careful endoscopic evaluation in similar clinical scenarios.
Red wale signs are indicators of active or recent bleeding from varices. Their presence in the same column as nonbleeding varices suggests higher risk for hemorrhage.
Variceal banding ligation involves placing elastic bands around the varices to stop bleeding and reduce the risk of rebleeding.
The location of varices in the esophagus influences bleeding risk and treatment strategy. Upper and middle third varices may require different management approaches.
The white nipple sign is a stigmata of recent bleeding and indicates a higher likelihood of active or impending hemorrhage from varices.
Yes, nonbleeding and active bleeding varices can be found in the same column, as observed in this case report.
The absence of red wale signs in nonbleeding varices suggests lower risk of active bleeding and may guide treatment decisions.