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Intergenerational effect of short-term spaceflight in mice.

Keisuke Yoshida1, Shin-Ichiro Fujita2, Ayako Isotani3

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Spaceflight impacts male mice germ cells, altering gene regulation and small RNA expression. Their offspring show increased DNA replication gene expression, indicating a transgenerational effect of space travel.

Keywords:
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Area of Science:

  • Reproductive biology
  • Space medicine
  • Genetics

Background:

  • Space travel is becoming more accessible.
  • Effects of spaceflight (microgravity, radiation, stress) on mammals are not fully understood.
  • The impact on offspring of space-traveling parents, especially male germ cells, is understudied.

Purpose of the Study:

  • To investigate the effects of spaceflight on male germ cells.
  • To determine if spaceflight has intergenerational effects on offspring.

Main Methods:

  • Male mice underwent 35 days of spaceflight.
  • Analysis of transcription factor ATF7 binding in testes.
  • Small RNA expression profiling in spermatozoa.
  • Gene expression analysis in the liver of offspring.

Main Results:

  • Spaceflight altered ATF7 binding on promoter regions in the testes of male mice.
  • Spaceflight led to changes in small RNA expression in spermatozoa.
  • Offspring of space-traveled males exhibited elevated hepatic expression of DNA replication-related genes.

Conclusions:

  • Spaceflight induces epigenetic and molecular changes in male germ cells.
  • These changes can be transmitted to offspring, resulting in altered gene expression.
  • Spaceflight has demonstrable intergenerational effects in mammals.