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IgA Nephropathy After SARS-CoV-2 Vaccination.

Matthew Abramson¹, Samuel Mon-Wei Yu¹, Kirk N Campbell¹

¹Division of Nephrology Icahn School of Medicine at Mount Sinai, New York, New York.

Kidney Medicine

|July 19, 2021

Summary

A case study reports IgA nephropathy (IgAN) in a man after his second mRNA-1273 SARS-CoV-2 vaccine dose. This highlights the need to study vaccine immune responses and watch for kidney symptoms like hematuria or proteinuria.

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Published on: July 3, 2013

Area of Science:

Nephrology
Immunology
Vaccinology

Background:

The SARS-CoV-2 pandemic spurred rapid development of mRNA vaccines.
Understanding the full spectrum of vaccine-induced immune responses is crucial.

Observation:

A 30-year-old man developed gross hematuria and proteinuria 24 hours post-mRNA-1273 SARS-CoV-2 vaccination.
Kidney biopsy confirmed a new diagnosis of IgA nephropathy (IgAN).

Findings:

The patient's IgAN was treated with an angiotensin receptor blocker, leading to reduced proteinuria.
The study hypothesizes de novo antibody formation against the SARS-CoV-2 spike protein's receptor-binding domain (RBD) due to unique glycosylation and potent immune stimulation by mRNA vaccines.

Implications:

This case underscores the need for further research into the immunological effects of mRNA SARS-CoV-2 vaccines in diverse populations.
Nephrologists should consider IgAN in patients presenting with new-onset hematuria or proteinuria post-vaccination.