Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphometrical and functional correlations in benign nephrosclerosis.

R Katafuchi1, S Takebayashi

  • 1Second Department of Pathology, Fukuoka University School of Medicine, Japan.

Clinical Nephrology
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic factors for idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and intravenous steroids.

The Journal of laryngology and otology·2016
Same author

Expression of aquaporins and vasopressin type 2 receptor in the stria vascularis of the cochlea.

Hearing research·2009
Same author

Glomerular crescent formation in renal amyloidosis. A clinicopathological study and demonstration of upregulated cell-mediated immunity.

Clinical nephrology·2008
Same author

Low-dose prednisolone ameliorates acute renal failure caused by cholesterol crystal embolism.

Clinical nephrology·2006
Same author

Resolution of primary amyloidosis by melphalan and prednisolone: a case report.

Clinical nephrology·2005
Same author

Factors affecting clinical outcome of patients who undergo transcatheter arterial embolisation in splenic injury.

The British journal of radiology·2004
Same journal

Clinical characteristics and outcomes of adults with minimal change disease: A retrospective, cross-sectional study.

Clinical nephrology·2026
Same journal

Analysis of end-stage renal disease mediated by cuproptosis-related genes.

Clinical nephrology·2026
Same journal

The relationship between red cell distribution width and platelet ratio in acute kidney injury among ventilator-associated pneumonia patients: A MIMIC-IV database study.

Clinical nephrology·2026
Same journal

Arterial stiffness and choroidal vascularity index in autosomal dominant polycystic kidney disease with preserved kidney function.

Clinical nephrology·2026
Same journal

Antibody-drug conjugate therapy in a renal transplant patient with bladder cancer: A case report.

Clinical nephrology·2026
Same journal

Epigenetic age enhances eGFR-based prediction of all-cause mortality: A cross-cohort validation of a novel risk model.

Clinical nephrology·2026
See all related articles

Intimal thickening in small arteries, not hyaline change, contributes to kidney damage and reduced function in hypertensive patients. This vascular change is linked to high blood pressure and hypertension duration.

Area of Science:

  • Nephrology
  • Pathology
  • Hypertension Research

Background:

  • Essential hypertension can lead to kidney damage.
  • Vascular lesions in the kidneys may cause ischemia and impair renal function.
  • Benign nephrosclerosis is a common complication of hypertension.

Purpose of the Study:

  • To investigate the relationship between vascular lesions and kidney damage in patients with essential hypertension.
  • To determine if ischemia caused by vascular lesions leads to impaired renal function.
  • To correlate morphometrical findings in renal biopsies with renal function.

Main Methods:

  • Analysis of 36 renal biopsies from Japanese patients with benign nephrosclerosis.
  • Morphometrical investigation of glomerular sclerotic index (GS), interstitial volume (IV), arteriolar hyaline change (HC), and intimal thickening (IT).

Related Experiment Videos

  • Classification of arteries based on medial smooth muscle cell (SMC) layers (SMC < 3 and SMC ≥ 3).

    • Main Results:

    • Intimal thickening (IT) in small arteries (SMC < 3) correlated significantly with glomerular sclerosis (GS) and interstitial volume (IV).
    • IT (SMC < 3), GS, and IV showed significant correlations with creatinine clearance (Ccr).
    • IT (SMC < 3) and HC correlated with blood pressure and hypertension duration, while IT (SMC ≥ 3) did not.

    Conclusions:

    • Intimal thickening of small arteries and arterioles (SMC < 3) is closely related to high blood pressure.
    • Intimal thickening, rather than hyaline change, in small arteries is implicated in renoparenchymal damage via ischemia.
    • These vascular changes contribute to the deterioration of renal function in patients with benign nephrosclerosis.