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Updated: Oct 27, 2025
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Molar pregnancy after in vitro fertilization with euploid single embryo transfer
Beth Zhou1, Helen Paige Anglin1, Alexander M Quaas1,2
1Division of Reproductive Endocrinology and Infertility, University of California, San Diego, California.
Objective:
To describe a case of molar pregnancy after in vitro fertilization (IVF) resulting from the transfer of a euploid embryo derived from a monopronuclear zygote.
Design:
Case report and review of the literature.
Setting:
Private practice IVF center.
Patients:
A 42-year-old woman, gravida 3 para 0, with advanced maternal age and infertility who underwent IVF.
Interventions:
Preimplantation genetic testing for aneuploidy using next-generation sequencing, single frozen euploid blastocyst transfer, and medical management of suspected missed abortion.
Main Outcome Measures:
Genetic examination of products of conception and correlation with embryonic preimplantation genetic testing for aneuploidy results.
Results:
Transfer of the euploid embryo derived from an abnormally fertilized oocyte (monopronuclear zygote) resulted in a clinical pregnancy suspected to be a missed abortion. Products of conception collected after medical management of the suspected missed abortion were analyzed using next-generation sequencing with the report "46,XX complete molar pregnancy".
Conclusions:
To our knowledge, this is the first account of a complete molar pregnancy resulting from the transfer of a reported euploid embryo, highlighting the importance of understanding the limitations of genetic testing platforms in the setting of abnormally fertilized oocyte-derived embryos.
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