Related Experiment Video
Updated: Oct 27, 2025

Author Spotlight: Development and Characterization of a Mouse Model for Abdominal Aortic Aneurysm
Published on: August 2, 2024
Mechanisms of abdominal aortic aneurysm progression: A review
1Department of Vascular Surgery, Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China.
Abstract:
Abdominal aortic aneurysm (AAA) is a common disease associated with significant cardiovascular morbidity and mortality. Up to now, there is still controversy on the choice of treatment method of AAA. Even so, the mechanisms of AAA progression are poorly defined, making targeting new therapies problematic. Current evidence favors an interaction of the hemodynamic microenvironment with local and systemic immune responses. In this review, we aim to provide an update of mechanisms in AAA progression, involving hemodynamics, perivascular adipose tissue, adventitial fibroblasts, vasa vasorum remodeling, intraluminal thrombus, and distribution of macrophage subtypes.
Related Concept Videos
Aneurysm I: Introduction
Aneurysm III: Interprofessional Care
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aortic Regurgitation I: Introduction
Atherosclerosis I: Introduction
Peripheral Artery Disease I: Introduction

