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Insoluble uricase in liver peroxisomes of Old World monkeys
S Fujiwara1, K Nakashima, T Noguchi
1Department of Biochemistry, Kyushu Dental College, Kitakyushu, Japan.
Abstract:
1. Subcellular localization form and properties of liver uricase of Macaca fascicularis were examined. 2. Uricase was present as the insoluble form in the peroxisomal core. 3. Evidence was obtained to show that the peroxisomal core is uricase itself. 4. The number and mol. wts of the subunits of the enzyme were identical to those of rat liver uricase. 5. The same results were also obtained for liver uricase of Macaca fuscata.