Related Experiment Video
Updated: Oct 27, 2025
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
11.4K
Circulating Bile Acid Profiles: A Need for Further Examination.
Li Qi1, Yu Tian2, Yongsheng Chen2
1Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, 110022, Liaoning Province, China.
The Journal of Clinical Endocrinology and Metabolism
|July 19, 2021
Summary
Altered bile acid (BA) levels are linked to metabolic disorders like obesity and type 2 diabetes. Monitoring BA profiles may help predict and manage these conditions, including metabolic associated fatty liver disease (MAFLD).
Area of Science:
- Metabolic physiology
- Chronobiology
- Biomarker discovery
Background:
- Bile acids (BAs) integrate metabolic and chronobiologic signals, influencing systemic responses to nutrient availability.
- Abnormalities in circulating BA concentration or composition are linked to metabolic disorders including obesity, type 2 diabetes mellitus (T2DM), insulin resistance (IR), and metabolic associated fatty liver disease (MAFLD).
Purpose of the Study:
- To review evidence connecting aberrant circulating BA profiles with metabolic disorders.
- To explore potential mechanisms underlying these associations.
- To evaluate the role of BA profiling as a novel biomarker for metabolic abnormalities.
Main Methods:
- Systematic literature review using PubMed.
- Keywords included "bile acids," "T2DM," "IR," and "MAFLD."
- Analysis of primary and review articles.
Main Results:
- Obese and IR individuals exhibit elevated fasting BAs but reduced postprandial increases compared to controls.
- Disrupted synchronization between feeding/fasting cycles and BA-regulated pathways may underlie these alterations.
- While BA alterations' direct link to MAFLD is unclear, elevated fasting BAs correlate with advanced fibrosis risk in MAFLD patients.
Conclusions:
- Circulating BA alterations (concentration, composition, rhythm) are associated with adverse systemic metabolic events.
- Further research into BA kinetics could aid in predicting metabolic disorders and guiding therapies.
- Dynamic monitoring of BA profiles shows promise for MAFLD patient stratification.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
37
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
37
01:19Bile
2.2K
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
Bile is released when dietary fats enter...
2.2K
01:16Hepatic Drug Excretion: Influencing Factors
292
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
292
01:30Serum Laboratory Studies, Stool Test, Breath Test
513
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
513
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
364
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
364
01:29Chronic Pancreatitis II: Collaborative Care
149
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
149